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A number of important concepts emerged. One like that in particular, the importance of epigenetics in gene regulation jumps out. Field epigenetics has boomed over the past 10 years. Clearly, chromatin provides the ideal
a platform for various post-translational modifications on DNA and histones that act as a signaling platform for various cellular processes.
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I also think that finding that a combination of four transcription factors can induce a pluripotent state was phenomenal and has stimulated much research in the field of stem cells1. Last but not least, the involvement of non-coding RNAs in various cellular and nuclear processes is absolutely fascinating. Mechanisms thereby
which long non-coding RNAs regulate gene expression await exciting discoveries flight.
BIO302 MIDTERM SOLVED PAPERS:
Elaine Fuchs. For the field of stem cells, there is no doubt that the findings of Shinya Yamanaka and his collaborator Kazutoshi Takahashi were changing the paradigm. Their work heralded creation of induced pluripotent stem (iPS) cells from mouse skin fibroblasts when cultured in embryonic medium stem cell (ESC) conditions1